Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology
Szebnyi K, Wenger LMD, Sun Y, Dunn AWE, Limegrover CA, Gibbons GM, Conci E, Paulsen O, Mierau SB, Balmus G* and Lakatos A*.
Nature Neuroscience · 2021
Research overview
Human cortical organoid slice cultures derived from patient-specific stem cells provide a model of early ALS/FTD pathology. The study identifies distinct disturbances in astroglia and neurons, including DNA damage and changes in proteostasis, and explores pharmacological rescue of neuronal pathology.