Publications

Explore research from the lab and our collaborators across genome stability, neuroscience and disease biology.

Includes journal articles, reviews and clearly labelled preprints. Publication list updated on 22 October 2026.

43 publications

2026
Preprint · not peer reviewedDecoding the naked mole-rat genome, telomere to telomere

Sokolowski DJ, Nater A, Miclaus M, Meng W, Monis S, Ngan WY, Qu R, Erdmann J, Fontanilla AM, Trifonov V, Yoo D, Alvi SA, Barker AJ, Barrenada-Taleb O, Bayerl J, Begay V, Campos AC, Chan C, Clarke Z, Erdmann AL, Faykoo-Martinez M, Geib T, Hoekzema K, Jiang Y, Karimpour N, Kumaragurubaran R, Ling S, Leordean D, Maree L, Mendez-Aranda D, Peng X, Prokopov D, Tang H, Ungerleider K, van der Horst G, Wu H, Zhou D, Zuzarte P, Haggerty L, Hou H, Hourlier T, Lischer H, Martin F, Gahurova L, Pugh TJ, Bennett NC, Hart DW, Howard JC, Borchers CH, Brieno-Enriquez MA, Laird DJ, Lewin GR, Holmes MM, Smith ESJ, Eichler EE, Bruggmann R, Lilue J, Simpson JT, Wilson MD, Balmus G.

bioRxiv · Preprint, not peer reviewed. First posted 16 October 2026. DOI: 10.64898/2026.10.14.758906

bioRxiv
2026
Preprint · not peer reviewedUnscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

Fernandez JP, Gärtner A, Perez-Perez J, Cumming SA, Feng J, van Belois K, He K, Yang D, Castells-Esteve C, Bergé-Gardeñes M, Bergander AL, Lubieniecki KP, Miclăuș M, Fissolo N, Comabella M, Vogt A, Gebauer L, Cavaleri F, Voelkner C, Illarionova A, Limbani H, Marke G, Chen RZ, Prasad BC, Vogt TF, Reid DA, Pinto RM, Podlesniy P, Kulisevsky J, Balmus G, Nguyen HP, Pouladi MA, Monckton DG, Brito V, Beuzer P.

bioRxiv · Preprint, not peer reviewed. First posted 2026-07-29. DOI: 10.64898/2026.07.29.741355

bioRxiv
2026
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

Morcom L, Xia W, Xu Z, Awasthi Y, Geywitz C, Ellis MO, Noli T, Zulji A, Yamamoto D, Girdler GC, Kai L, Zhu K, Wei M, Tang XY, Hoi KK, Gonzalez-Maya J, Duncan GJ, Vaquie AM, Gold Diaz D, Kawaguchi R, Liu E, Sun Y, Yang D, Jordan GD, Lu IL, Holmqvist S, Bartels T, Ridley K, Choi JJ, Franco SJ, Huang EJ, Emery B, Geschwind D, Schirmer L, Balmus G, Popko B, Fancy SPJ, Rowitch DH.

Nature 653(8115): 809-818 (2026). DOI: 10.1038/s41586-026-10310-3

Nature
2025
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

Park B, Nicaise AM, Tsitsipatis D, Pirvan L, Zucha D, Munteanu A, Prasad P, De Novales MLL, Bulgaru C, Kollyfas R, Whitten J, Willis CM, Culig L, Llewellyn J, Ionescu RB, Mekdad M, Simões-Abade MBC, Krzak G, Fan J, De S, Ellis MO, Cubero MS, Spathopoulou A, Peruzzotti-Jametti L, Leonardi T, Balmus G, Edenhofer F, Gorospe M, Valihrach L, Mohorianu I, Pluchino S, Beerman I.

Neuron 113(24): 4158-4177.e10 (2025). DOI: 10.1016/j.neuron.2025.09.022

Neuron
2025
Gene context drift identifies drug targets to mitigate cancer treatment resistance

Jassim A, Nimmervoll BV, Terranova S, Nathan E, Hu L, Taylor JT, Masih KE, Ruff L, Duarte M, Cooper E, Katyal G, Akhbari M, Gilbertson RJ, Coleman JC, Toker JS, Terhune C, Balmus G, Jackson SP, Liu H, Jiang T, Taylor MD, Hua K, Abraham JE, Filbin MG, Hill A, Patrizi A, Dani N, Regev A, Lehtinen MK, Gilbertson RJ.

Cancer Cell 43(9): 1608-1621.e9 (2025). DOI: 10.1016/j.ccell.2025.06.005

Cancer Cell
2025
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types

Chan PY, Alexander D, Mehta I, Matsuyama LSAS, Harle V, Olvera-León R, Park JS, Arriaga-González FG, van der Weyden L, Cheema S, Iyer V, Offord V, Barneda D, Hawkins PT, Stephens L, Kozik Z, Woods M, Wong K, Balmus G, Vinceti A, Thompson NA, Del Castillo Velasco-Herrera M, Wessels L, van de Haar J, Gonçalves E, Sinha S, Vázquez-Cruz ME, Bisceglia L, Raimondi F, Choudhary J, Patiyal S, Venkatesh A, Iorio F, Ryan CJ, Adams DJ.

Nature Genetics 57(7): 1672-1683 (2025). DOI: 10.1038/s41588-025-02222-1

Nature Genetics
2025
Preprint · not peer reviewedExtrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival

Brückner L, Xu R, Tang J, Gnanasekar A, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Montouri G, Pradella D, Ilić M, Suina K, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu-Kraljič M, Herzog S, Hollinger A, Wittstruck N, Fernandez M, Wolozyn N, Becker F, Louma V, Yan X, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Dawes C, Balmus G, Hero B, Fischer M, Bafna V, Verhaak R, Wahl G, Liu Y, Koche RP, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Scheer M, Werner B, Chang HY, Mischel PS, Henssen AG.

bioRxiv · Preprint, not peer reviewed. First posted 2025-04-18. DOI: 10.1101/2025.04.15.648906 Revised 19 February 2026.

bioRxiv
2024
Mitochondrial complex I activity in microglia sustains neuroinflammation

L Peruzzotti-Jametti, CM Willis, G Krzak, R Hamel, L Pirvan, R-B Ionescu, JA Reisz, HA Prag, ME Garcia-Segura, V Wu, Y Xiang, B Barlas, AM Casey, AMR van den Bosch, AM Nicaise, L Roth, GR Bates, H Huang, P Prasad, AE Vincent, C Frezza, C Viscomi, G Balmus, Z Takats, JC Marioni, A D’Alessandro, MP Murphy, I Mohorianu, S Pluchino (2024)

Nature 628 , 195–203

Nature
2024
Natural language processing charts transcriptome evolution to design combination cancer therapies

Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Linda P Hu, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson (2024)

ioRxiv preprint doi: https://doi.org/10.1101/2024.04.09.585681

bioRxiv · preprint
2017
The non-homologous end joining protein PAXX acts to restrict HSV-1 infection

Trigg B, Lauer K, Fernandes dos Santos P, Coleman H., Balmus G, Mansur G, Ferguson B (2017)

Viruses 9 (11), 342 full text

Viruses
2016
Synthetic lethality between PAXX and XLF in mammalian development

Balmus G, Barros AC, Wijnhoven PWG, Lescale C, Hasse HL, Boroviak K, et al. (2016)

Genes & Dev . 30:2152-2157

Genes & Dev
2016
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Lescale C, Hasse HL, Blackford AN, Balmus G, Bianchi JJ, Yu W, et al. (2016)

Cell Reports 16(11), 2967-2997

Cell Reports
2016
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice

McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ (2016)

G3 6, 82343-2354

G3
2016
HUS1 regulates in vivo responses to genotoxic chemotherapies

Balmus G, Lim PX, Oswald A, Hume KR, Cassano A, Pierre J, et al. (2016)

Oncogene 35: 662–669

Oncogene
2015
A high- throughput in vivo micronucleus assay for genome stability screening in the mouse

Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ and McIntyre RE (2015)

Nature protocols 10(1): 205-215

Nature Protocols
2014
Genetic screens in mice for genome integrity maintenance and cancer predisposition

Balmus G, and McIntyre RE. (2014).

Curr. Opin. Genet. Dev. 24: 1–7

Curr. Opin. Genet. Dev.
2012
Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1

Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, et al. (2012).

Human molecular genetics 21: 3408–3420

Human molecular genetics
2012
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease

Daugherity EK, Balmus G, Saei AA, Moore ES, Abdallah DA, Rogers AB, et al. (2012).

Cell Cycle 11: 1918–1928

Cell Cycle
2012
A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice

Qi Q, Huang W, Bai Y, Balmus G, Weiss RS, and August A. (2012).

J Immunol 188: 3611–3619

J Immunol
2011
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis

Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, et al. (2011).

PLoS Genet. 7: e1002094

PLoS Genet.
2011
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Jinadasa R, Balmus G, Gerwitz L, Roden J, Weiss R, and Duhamel G. (2011).

Journal of Visualized Experiments 50:2598

Journal of Visualized Experiments
2007
Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype

Balmus G, Trifonov VA, Biltueva LS, O'Brien PC, Alkalaeva ES, Fu B, et al. (2007).

Chromosome Research 15: 499–514

Chromosome Research
2006
Cytogenetic characterization of alpaca (Lama pacos, fam. Camelidae) prometaphase chromosomes

Di Berardino D, Nicodemo D, Coppola G, King AW, Ramunno L, Cosenza GF, Iannuzzi L, Di Meo GP, Balmus G, and Rubes J. (2006).

Cytogenetic and Genome Research 115: 138–144

Cytogenetic and Genome Research
2006
Chromosome localization of microsatellite markers in the shrews of the Sorex araneus group

Basset P, Yannic G, Yang F, O'Brien PCM, Graphodatsky AS, Ferguson-Smith MA, Balmus G, Volobouev VT, and Hausser J. (2006).

Chromosome Research 14: 253–262

Chromosome Research
2004
Clonal evolution of a mouse metastatic hemangiosarcoma

Carlan M, Carlan AF and Balmus G (2004).

Analele Stiintifice ale Universitatii" Alexandru Ioan Cuza" din Iasi Sec. II a. Genetica si Biologie Moleculara 5.1

Analele Stiintifice ale Universitatii" Alexandru Ioan Cuza" din Iasi Sec. II a. Genetica si Biologie Moleculara