Recent publications, research programmes and life in Cambridge.
· Preprint
Our collaborative bioRxiv preprint presents a telomere-to-telomere naked mole-rat genome assembly, annotated using data from 23 tissues. The resource enables studies of genome stability and the genetic basis of the species’ distinctive biology.
Read the bioRxiv preprint· Publication
A collaborative study with the Jackson Laboratory identifies epigenetic regulators that can restore sensitivity to ATR inhibition in experimental cancer models.
Read the paper· Research programme
Gabriel Balmus and Sarah Tabrizi are advancing a project supported by stage II of the UK DRI Key Questions programme, aiming to identify compounds that selectively target DNA repair pathways involved in CAG repeat expansion.
Read the UK DRI announcement· Publication
A study in Nature links DNA damage and repair capacity to selective neuronal vulnerability during neuroinflammation.
Explore the research highlight· Publication
Collaborative work in Science Translational Medicine supports targeting MSH3 to limit CAG repeat expansion in patient-derived striatal neurons.
Explore the research highlight
Following a seminar from our guest Daniel Reumann about his research in the Knoblich Laboratory, we had our first in-person get-together of the year at one of the Cambridge colleges.
Meet the lab