Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
Dev H et al. (2018) -
Nature Cell Biology · 2018
Research overview
Whole-genome CRISPR–Cas9 screens identified the Shieldin complex as an effector of DNA double-strand break repair. The study explores how Shieldin restricts end resection, promotes end-joining and influences responses to PARP inhibitors in BRCA1-deficient cells.